This entry comprises the dataset of TiO2-Nb2O5 based nanomaterials, composed of mixed Ti-Nb and TiO2@Nb2O5 core@shell oxides. These materials were characterized using: (1) X-ray scattering techniques to probe structural properties, including X-ray diffraction (XRD) and pair distribution function (PDF) analysis; (2) the adsorption of probe molecules to evaluate their acidity, including nuclear magnetic resonance (NMR) of phosphorus isotope (31P) of adsorbed trimethylphosphine oxide (TMPO), Fourier transform infrared spectroscopy (FTIR) of adsorbed pyridine (Py), and temperature programmed desorption (TPD) of ammonia (NH3). Here, we also include the data regarding the catalytic evaluation of metal-supported catalysts using the TiO2-Nb2O5 materials as support in the acetone hydrodeoxygenation (HDO) reaction.