Since the last century, various territories dedicated to knowledge production have emerged, such as university campuses, Science and Technology Parks, and more recently, innovation districts. Over the past decades, with the growth of the knowledge-based services sector, they have evolved in parallel with different innovation models, incorporating greater social and environmental concerns based on the Quintuple helix model. The related article investigates the strategies and approaches adopted in the transition of knowledge production territories to what some authors are calling the fourth generation, using the urban development initiative Paris-Saclay and the university campus distrotec, located respectively in France and Mexico, as case studies. This supplementary dataset presents the analytical model that allows for the comparison between different knowledge production territories (KPTs) regarding their level of development towards the fourth-generation concept, this analysis table was developed. It adapts the work of Liu et al. (2021), which includes 50 metrics for evaluating sustainable urban infrastructures, and adapted it for the analysis of the fourth-generation innovation district, Paris-Saclay. This research expands that framework, including KBUD indicators such as housing, social inclusion, and social diversity (Esmaeilpoorarabi, 2018). Two existing frameworks were used as the method of analysis: a) the TBL construct, proposed by Elkington (1997), which evaluates sustainability in companies based on the economic, social, and environmental dimensions; b) and KBUD, which originates from the TBL model, focused on KPTs. From this, two case studies were conducted in existing KPTs to compile their best practices within these theoretical pillars: a) the Paris-Saclay urban operation, located south of Paris, France; b) and the Distritotec university campus in Monterrey, Mexico. This would, therefore, be the path for the validation of the initial study. The adopted method allowed for the creation of an analytical procedure that catalogs best practices observed for each indicator in the case studies, using secondary data from documents, official websites, and articles on these territories. After the analysis, the practices applied to each indicator were identified, and a generic table with indicators and possible application practices was created to serve as a comparison between them.