| dc.contributor |
Universidade Estadual Paulista (UNESP) |
|
| dc.creator |
Dias, Mirela B. |
|
| dc.creator |
Gargaglioni, Luciane H |
|
| dc.creator |
Patrone, Luis G.A. |
|
| dc.creator |
Rodrigues, Laísa TC |
|
| dc.date |
2022-06-20T18:14:40Z |
|
| dc.date |
2022-06-20T18:14:40Z |
|
| dc.date |
2022 |
|
| dc.date.accessioned |
2024-09-24T16:48:30Z |
|
| dc.date.available |
2024-09-24T16:48:30Z |
|
| dc.identifier |
http://hdl.handle.net/11449/235199 |
|
| dc.identifier |
3203493045928389 |
|
| dc.identifier |
5850453468994497 |
|
| dc.identifier |
8833369074938340 |
|
| dc.identifier |
0000-0002-4084-3139 |
|
| dc.identifier |
0000-0002-8270-1892 |
|
| dc.identifier |
0000-0003-4097-5286 |
|
| dc.identifier |
0000-0003-3704-6099 |
|
| dc.identifier.uri |
https://metabuscador.uspdigital.usp.br/xmlui/handle/doc/16431 |
|
| dc.description |
Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide involved in a broad range of homeostatic functions including regulation of the hypercapnic chemoreflex. We evaluated whether MCH modulates the hypercapnic ventilatory response by acting in the lateral hypothalamic area (LHA) and/or in the locus coeruleus (LC). Here, we measured pulmonary ventilation ( E), body temperature, EEG and EMG of unanesthetized male Wistar rats before and after microinjection of MCH [0.4 mM] into the LHA and LC, or the MCH1-R antagonist (SNAP-94847 [63 mM]), into the LHA, in room air and in 7% CO2 during wakefulness and sleep, in the dark and light periods. MCH intra-LHA caused a decreased CO2 ventilatory response during wakefulness and sleep, while SNAP-94847 intra-LHA increased this response, during wakefulness in the light period. In the LC, MCH or the MCH1-R antagonist caused no change in the hypercapnic ventilatory response. Our results suggest that MCH, in the LHA, exerts an inhibitory modulation of the hypercapnic ventilatory response during the light-inactive period in rats. |
|
| dc.description |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) |
|
| dc.description |
Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior (CAPES) |
|
| dc.description |
FAPESP:2019/17693-5 |
|
| dc.description |
FAPESP: 2018/01781-0 |
|
| dc.description |
CAPES: 88887.194785/2018-00 |
|
| dc.format |
pdf |
|
| dc.format |
application/pdf |
|
| dc.format |
application/pdf |
|
| dc.format |
application/pdf |
|
| dc.format |
application/pdf |
|
| dc.format |
application/pdf |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.rights |
info:eu-repo/semantics/openAccess |
|
| dc.subject |
Breathing |
|
| dc.subject |
Chemoreceptors |
|
| dc.subject |
Hypothalamus |
|
| dc.subject |
Breathing |
|
| dc.title |
Melanin-concentrating hormone regulates the hypercapnic chemoreflex by acting in the lateral hypothalamic area |
|
| dc.type |
info:eu-repo/semantics/dataset |
|