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Patterns of vascular response immediately after passive mobilization in patients with sepsis an observational transversal study

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dc.contributor.author Kawakami, Débora Mayumi de Oliveira
dc.contributor.author Bonjorno Junior, José Carlos
dc.contributor.author Destro, Tamara Rodrigues da Silva
dc.contributor.author Biazon, Thaís Marina Pires de Campos
dc.contributor.author Garcia, Naiara Molina
dc.contributor.author Bonjorno, Flávia Cristina Rossi Caruso
dc.contributor.author Silva, Audrey Borghi
dc.contributor.author Mendes, Renata Gonçalves
dc.date.accessioned 2022-02-10T09:57:19Z
dc.date.available 2022-02-10T09:57:19Z
dc.date.issued 2021-09-18
dc.identifier https://doi.org/10.1007/s10554-021-02402-0 por
dc.identifier.citation KAWAKAMI, Débora Mayumi de Oliveira; BONJORNO JUNIOR, José Carlos; DESTRO, Tamara Rodrigues da Silva; BIAZON, Thaís Marina Pires de Campos; GARCIA, Naiara Molina; BONJORNO, Flávia Cristina Rossi Caruso; SILVA, Audrey Borghi; MENDES, Renata Gonçalves. Patterns of vascular response immediately after passive mobilization in patients with sepsis an observational transversal study. Repositório Institucional da UFSCar, 2021. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15583. *
dc.identifier.uri https://repositorio.ufscar.br/handle/ufscar/15583
dc.description Sepsis is a serious organ dysfunction leading to endothelial damage in critical patients. Physiologically, there is an augment of vascular diameter in response to increased vascular blood flow and shear stress stimulus. However, the pattern of vascular response in face of passive mobilization (PM), an early mobilization physical strategy, has not yet been explored in patients with sepsis. To explore patterns of vascular response to PM and associations with clinical and cardiovascular profile in patients with sepsis. Cross-sectional, single-arm study. Thirty-two patients diagnosed with sepsis were enrolled. Vascular response was assessed by flow-mediated dilation (FMD) using brachial artery ultrasound, before and after PM. The PM (to assess the response pattern) and SR (shear rate) were also calculated. PM protocol consisted of knees, hips, wrists, elbows, shoulders, dorsiflexion/plantar flexion movements 3 × 10 repetitions each (15 min). Arterial stiffness was assessed by Sphygmocor®, by analyzing the morphology and pulse wave velocity. Cardiac autonomic modulation (CAM) was assessed by analyzing heart rate variability indexes (mean HR, RMSSD, LF, HF, ApEn, SampEn, DFA). Different vascular responses were observed after PM: (1) increased vascular diameter (responders) (n = 13, %FMD = 11.89 ± 5.64) and (2) reduced vascular diameter (non-responders) (n = 19, %FMD= -7.42 ± 6.44). Responders presented a higher non-linear DFA2 index (p = 0.02). There was a positive association between FMD and DFA (r = 0.529; p = 0.03); FMD and SampEn (r = 0.633; p < 0.01). A negative association was identified between FMD and LF (Hz) (r= -0.680; p < 0.01) and IL-6 (r= -0.469; p = 0.037) and SR and CRP (r= -0.427; p = 0.03). eng
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) por
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) por
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) por
dc.language.iso eng eng
dc.publisher Universidade Federal de São Carlos por
dc.relation.uri https://pubmed.ncbi.nlm.nih.gov/34535852/ por
dc.relation.uri https://repositorio.ufscar.br/handle/ufscar/14137 por
dc.rights Attribution-NonCommercial-NoDerivs 3.0 Brazil *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/br/ *
dc.subject Endothelium eng
dc.subject Exercise eng
dc.subject Flow-mediated dilatation analysis eng
dc.subject Inpatient eng
dc.title Patterns of vascular response immediately after passive mobilization in patients with sepsis an observational transversal study eng
dc.type Dataset eng
dc.description.sponsorshipId Processo nº 2015/26501–1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) por
dc.description.sponsorshipId Código de Financiamento 001 - CAPES por
dc.description.sponsorshipId Processo nº 428073/2016-6 - Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) por


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