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Non-invasive ventilation improves exercise tolerance and peripheral vascular function after high-intensity exercise in COPD-HF patients

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dc.contributor.author Goulart, Cássia da Luz
dc.contributor.author Caruso, Flávia Rossi
dc.contributor.author Araújo, Adriana Sanches Garcia de
dc.contributor.author Arêas, Guilherme Peixoto Tinoco
dc.contributor.author Moura, Silvia Cristina Garcia de
dc.contributor.author Catai, Aparecida Maria
dc.contributor.author Mendes, Renata Gonçalves
dc.contributor.author Phillips, Shane A.
dc.contributor.author Arena, Ross
dc.contributor.author Silva, Andréa Lúcia Gonçalves da
dc.contributor.author Silva, Audrey Borghi
dc.date.accessioned 2022-02-10T09:42:27Z
dc.date.available 2022-02-10T09:42:27Z
dc.date.issued 2020-09-25
dc.identifier https://doi.org/10.1016/j.rmed.2020.106173 por
dc.identifier.citation GOULART, Cássia da Luz; CARUSO, Flávia Rossi; DE ARAÚJO, Adriana Sanches Garcia; ARÊAS, Guilherme Peixote Tinoco; DE MOURA, Silvia Cristina Garcia; CATAI, Aparecida Maria; MENDES, Renata Gonçalves; PHILLIPS, Shane A.; ARENA, Ross; DA SILVA, Andréa Lúcia Gonçalves; BORGHI-SILVA, Audrey. Non-invasive ventilation improves exercise tolerance and peripheral vascular function after high-intensity exercise in COPD-HF patients. Repositório de Dados da UFSCar, 2020. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15580. *
dc.identifier.uri https://repositorio.ufscar.br/handle/ufscar/15580
dc.description Aim: Evaluate the acute effects of non-invasive positive pressure ventilation (NiPPV) during high-intensity exercise on endothelial function in patients with coexisting chronic obstructive pulmonary disease (COPD) and heart failure (HF). Methods: This is a randomized, double blinded, sham-controlled study involving 14 COPD-HF patients, who underwent a lung function test and Doppler echocardiography. On two different days, patients performed incremental cardiopulmonary exercise testing (CPET) and two constant-work rate tests (80% of CPET peak) receiving Sham or NiPPV (bilevel mode - Astral 150) in a random order until the limit of tolerance (Tlim). Endothelial function was evaluated by flow mediated vasodilation (FMD) at three time points: 1) Baseline; 2) immediately post-exercise with NiPPV; and 3) immediately post-exercise with Sham. Results: Our patients had a mean age of 70 ± 7 years, FEV1 1.9 ± 0.7 L and LVEF 41 ± 9%. NIPPV resulted in an increased Tlim (NiPPV: 130 ± 29s vs Sham: 98 ± 29s p = 0.015) and SpO2 (NiPPV: 94.7 ± 3.5% vs Sham: 92.7 ± 5.2% p = 0.03). Also, NiPPV was able to produce a significant increase in FMD (%) (NiPPV: 9.2 ± 3.1 vs Sham: 3.6 ± 0.7, p < 0.05), FMD (mm) (NiPPV: 0.41 ± 0.18 vs Sham: 0.20 ± 0.11, p < 0.05), Blood flow velocity (NiPPV: 33 ± 18 vs Baseline: 20 ± 14, p < 0.05) and Shear Stress (SS) (NiPPV: 72 ± 38 vs Baseline: 43 ± 25, p < 0.05). We found correlation between Tlim vs. ΔSS (p = 0.03; r = 0.57). Univariate-regression analysis revealed that increased SS influenced 32% of Tlim during exercise with NiPPV. Conclusion: NiPPV applied during high-intensity exercise can acutely modulate endothelial function and improve exercise tolerance in COPD-HF patients. In addition, the increase of SS positively influences exercise tolerance. eng
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) por
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) por
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) por
dc.language.iso eng eng
dc.publisher Universidade Federal de São Carlos por
dc.relation.uri https://pubmed.ncbi.nlm.nih.gov/33007709 por
dc.rights Attribution-NonCommercial-NoDerivs 3.0 Brazil *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/br/ *
dc.subject COPD eng
dc.subject Endothelial function eng
dc.subject Exercise test eng
dc.subject Heart failure eng
dc.subject Ventilation eng
dc.title Non-invasive ventilation improves exercise tolerance and peripheral vascular function after high-intensity exercise in COPD-HF patients eng
dc.type Dataset eng
dc.description.sponsorshipId Processo nº 2015/26501–1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) por
dc.description.sponsorshipId Código de Financiamento 001 - CAPES por
dc.description.sponsorshipId Processo nº 141803/ 2019 -3 - Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) por
dc.description.sponsorshipId Processo nº 2018/03233-0, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) por


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