dc.contributor.author |
Goulart, Cássia da Luz |
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dc.contributor.author |
Caruso, Flávia Rossi |
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dc.contributor.author |
Araújo, Adriana Sanches Garcia de |
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dc.contributor.author |
Arêas, Guilherme Peixoto Tinoco |
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dc.contributor.author |
Moura, Silvia Cristina Garcia de |
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dc.contributor.author |
Catai, Aparecida Maria |
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dc.contributor.author |
Mendes, Renata Gonçalves |
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dc.contributor.author |
Phillips, Shane A. |
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dc.contributor.author |
Arena, Ross |
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dc.contributor.author |
Silva, Andréa Lúcia Gonçalves da |
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dc.contributor.author |
Silva, Audrey Borghi |
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dc.date.accessioned |
2022-02-10T09:42:27Z |
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dc.date.available |
2022-02-10T09:42:27Z |
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dc.date.issued |
2020-09-25 |
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dc.identifier |
https://doi.org/10.1016/j.rmed.2020.106173 |
por |
dc.identifier.citation |
GOULART, Cássia da Luz; CARUSO, Flávia Rossi; DE ARAÚJO, Adriana Sanches Garcia; ARÊAS, Guilherme Peixote Tinoco; DE MOURA, Silvia Cristina Garcia; CATAI, Aparecida Maria; MENDES, Renata Gonçalves; PHILLIPS, Shane A.; ARENA, Ross; DA SILVA, Andréa Lúcia Gonçalves; BORGHI-SILVA, Audrey. Non-invasive ventilation improves exercise tolerance and peripheral vascular function after high-intensity exercise in COPD-HF patients. Repositório de Dados da UFSCar, 2020. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15580. |
* |
dc.identifier.uri |
https://repositorio.ufscar.br/handle/ufscar/15580 |
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dc.description |
Aim: Evaluate the acute effects of non-invasive positive pressure ventilation (NiPPV) during high-intensity exercise on endothelial function in patients with coexisting chronic obstructive pulmonary disease (COPD) and heart failure (HF). Methods: This is a randomized, double blinded, sham-controlled study involving 14 COPD-HF patients, who underwent a lung function test and Doppler echocardiography. On two different days, patients performed incremental cardiopulmonary exercise testing (CPET) and two constant-work rate tests (80% of CPET peak) receiving Sham or NiPPV (bilevel mode - Astral 150) in a random order until the limit of tolerance (Tlim). Endothelial function was evaluated by flow mediated vasodilation (FMD) at three time points: 1) Baseline; 2) immediately post-exercise with NiPPV; and 3) immediately post-exercise with Sham. Results: Our patients had a mean age of 70 ± 7 years, FEV1 1.9 ± 0.7 L and LVEF 41 ± 9%. NIPPV resulted in an increased Tlim (NiPPV: 130 ± 29s vs Sham: 98 ± 29s p = 0.015) and SpO2 (NiPPV: 94.7 ± 3.5% vs Sham: 92.7 ± 5.2% p = 0.03). Also, NiPPV was able to produce a significant increase in FMD (%) (NiPPV: 9.2 ± 3.1 vs Sham: 3.6 ± 0.7, p < 0.05), FMD (mm) (NiPPV: 0.41 ± 0.18 vs Sham: 0.20 ± 0.11, p < 0.05), Blood flow velocity (NiPPV: 33 ± 18 vs Baseline: 20 ± 14, p < 0.05) and Shear Stress (SS) (NiPPV: 72 ± 38 vs Baseline: 43 ± 25, p < 0.05). We found correlation between Tlim vs. ΔSS (p = 0.03; r = 0.57). Univariate-regression analysis revealed that increased SS influenced 32% of Tlim during exercise with NiPPV. Conclusion: NiPPV applied during high-intensity exercise can acutely modulate endothelial function and improve exercise tolerance in COPD-HF patients. In addition, the increase of SS positively influences exercise tolerance. |
eng |
dc.description.sponsorship |
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) |
por |
dc.description.sponsorship |
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) |
por |
dc.description.sponsorship |
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) |
por |
dc.language.iso |
eng |
eng |
dc.publisher |
Universidade Federal de São Carlos |
por |
dc.relation.uri |
https://pubmed.ncbi.nlm.nih.gov/33007709 |
por |
dc.rights |
Attribution-NonCommercial-NoDerivs 3.0 Brazil |
* |
dc.rights.uri |
http://creativecommons.org/licenses/by-nc-nd/3.0/br/ |
* |
dc.subject |
COPD |
eng |
dc.subject |
Endothelial function |
eng |
dc.subject |
Exercise test |
eng |
dc.subject |
Heart failure |
eng |
dc.subject |
Ventilation |
eng |
dc.title |
Non-invasive ventilation improves exercise tolerance and peripheral vascular function after high-intensity exercise in COPD-HF patients |
eng |
dc.type |
Dataset |
eng |
dc.description.sponsorshipId |
Processo nº 2015/26501–1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) |
por |
dc.description.sponsorshipId |
Código de Financiamento 001 - CAPES |
por |
dc.description.sponsorshipId |
Processo nº 141803/ 2019 -3 - Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) |
por |
dc.description.sponsorshipId |
Processo nº 2018/03233-0, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) |
por |