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Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study

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dc.contributor.author Heubel, Alessandro Domingues
dc.contributor.author Viana, Ariane Aparecida
dc.contributor.author Linares, Stephanie Nogueira
dc.contributor.author Amaral, Vanessa Teixeira do
dc.contributor.author Schafauser, Nathany Souza
dc.contributor.author Oliveira, Gustavo Yudi Orikassa de
dc.contributor.author Ramírez, Paula Camila
dc.contributor.author Martinelli, Bruno
dc.contributor.author Alexandre, Tiago da Silva
dc.contributor.author Silva, Audrey Borghi
dc.contributor.author Ciolac, Emmanuel Gomes
dc.contributor.author Mendes, Renata Gonçalves
dc.date.accessioned 2022-02-09T10:19:21Z
dc.date.available 2022-02-09T10:19:21Z
dc.date.issued 2021-11-23
dc.identifier https://doi.org/10.1002/oby.23311 por
dc.identifier.citation HEUBEL, Alessandro Domingues; VIANA, Ariane Aparecida; LINARES, Stephanie Nogueira; AMARAL, Vanessa Teixeira do; SCHAFAUSER, Nathany Souza; OLIVEIRA, Gustavo Yudi Orikassa de; RAMÍREZ, Paula Camila; MARTINELLI, Bruno; ALEXANDRE, Tiago da Silva; BORGHI-SILVA, Audrey; CIOLAC, Emmanuel Gomes; MENDES, Renata Gonçalves. Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study. Repositório de Dados da UFSCar, 2021. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15570. *
dc.identifier.uri https://repositorio.ufscar.br/handle/ufscar/15570
dc.description Objective: The aim of this study was to identify determinants of endothelial dysfunction in patients hospitalized with acute COVID-19. Methods: A total of 109 hospitalized COVID-19 patients in noncritical status were cross-sectionally studied. Clinical data (age, sex, comorbidities, and medications) and BMI were assessed. Laboratory tests included serum hemoglobin, leukocytes, lymphocytes, platelets, C-reactive protein, ferritin, D-dimer, and creatinine. Physical status was evaluated using a handgrip dynamometer. Endothelial function was assessed noninvasively using the flow-mediated dilation (FMD) method. Results: The sample average age was 51 years, 51% of patients were male, and the most frequent comorbidity was obesity (62%). Univariate analysis showed association of lower FMD with higher BMI, hypertension, use of oral antihypertensive, higher blood levels of creatinine, and larger baseline artery diameter. After adjusting for confounders, the multivariate analysis showed BMI (95% CI: −0.26 to −0.11; p < 0.001) as the major factor associated with FMD. Other factors associated with FMD were baseline artery diameter (95% CI: −1.77 to −0.29; p = 0.007) and blood levels of creatinine (95% CI: −1.99 to −0.16; p = 0.022). Conclusions: Increased BMI was the major factor associated with endothelial dysfunction in noncritically hospitalized COVID-19 patients. This may explain one of the pathways in which obesity may increase the risk for severe COVID-19. eng
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) por
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) por
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) por
dc.language.iso eng eng
dc.publisher Universidade Federal de São Carlos por
dc.relation.uri https://pubmed.ncbi.nlm.nih.gov/34554646/ por
dc.rights Attribution-NonCommercial-NoDerivs 3.0 Brazil *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/br/ *
dc.subject Covid-19 eng
dc.subject Endothelial function eng
dc.title Determinants of endothelial dysfunction in noncritically ill hospitalized COVID-19 patients: a cross-sectional study eng
dc.type Dataset eng
dc.description.sponsorshipId Código de Financiamento 001 - CAPES por
dc.description.sponsorshipId Processo nº 2015/09259‐2, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) por
dc.description.sponsorshipId Processo nº 2015/26501‐1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) por
dc.description.sponsorshipId Processo nº 303399/2018‐0 - Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) por


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Attribution-NonCommercial-NoDerivs 3.0 Brazil Exceto quando indicado o contrário, a licença deste item é descrito como Attribution-NonCommercial-NoDerivs 3.0 Brazil