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Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients

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dc.contributor.author Heubel, Alessandro Domingues
dc.contributor.author Kabbach, Erika Zavaglia
dc.contributor.author Schafauser, Nathany Souza
dc.contributor.author Di Lorenzo, Valéria Amorim Pires
dc.contributor.author Silva, Audrey Borghi
dc.contributor.author Mendes, Renata Gonçalves
dc.date.accessioned 2022-02-08T10:41:04Z
dc.date.available 2022-02-08T10:41:04Z
dc.date.issued 2021-05-01
dc.identifier https://doi.org/10.1016/j.rmed.2021.106389 por
dc.identifier.citation HEUBEL, Alessandro Domingues; KABBACH, Erika Zavaglia; SCHAFAUSER, Nathany Souza; DI LORENZO, Valéria Amorim Pires; SILVA, Audrey Borghi; MENDES, Renata Gonçalves. Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients. Repositório Institucional da UFSCar, 2021. Dataset. Disponível em: https://repositorio.ufscar.br/handle/ufscar/15555. *
dc.identifier.uri https://repositorio.ufscar.br/handle/ufscar/15555
dc.description Purpose: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is associated with an elevated risk of cardiovascular events, which can be linked to endothelial dysfunction. In this study, we aimed to investigate whether noninvasive ventilation (NIV) acutely changes endothelial function in hospitalized AECOPD patients. Methods: Twenty-one AECOPD patients were assessed in a hospital ward setting from 24 to 48 h after admission. NIV was applied using a ventilator with bilevel pressure support. Before and after NIV protocol, patients were evaluated regarding (1) endothelium-dependent function, assessed non-invasively using the flow-mediated dilation (FMD) method; (2) arterial blood gas analysis. Other baseline evaluations included clinical and anthropometric data, and laboratory tests. Results: The total group showed a significant improvement in FMD as a result of NIV effect (P = 0.010). While arterial carbon dioxide and oxygen were not altered, oxygen saturation increased after NIV (P = 0.045). The subgroup comparison of responders (FMD ≥ 1%) and non-responders (FMD < 1%) showed significant baseline differences in body mass index (BMI) (P = 0.019) and predicted forced expiratory volume in one second (FEV1) (P = 0.007). In univariate and multivariate analyses, both BMI and FEV1 were determinant for endothelial response to NIV. Conclusion: NIV acutely improves endothelial function in hospitalized AECOPD patients. Overweight and COPD severity may represent important characteristics for the magnitude of peripheral vascular response. eng
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) por
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) por
dc.language.iso eng eng
dc.publisher Universidade Federal de São Carlos por
dc.relation.uri https://www.resmedjournal.com/article/S0954-6111(21)00095-0/fulltext#relatedArticles por
dc.rights Attribution-NonCommercial-NoDerivs 3.0 Brazil *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/br/ *
dc.subject Chronic obstructive pulmonary disease eng
dc.subject Noninvasive ventilation eng
dc.subject Peripheral vascular function eng
dc.title Noninvasive ventilation acutely improves endothelial function in exacerbated COPD patients eng
dc.type Dataset por
dc.description.sponsorshipId Código de Financiamento 001 - CAPES por
dc.description.sponsorshipId Processo nº 2015/12763-4, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) por
dc.description.sponsorshipId Processo nº 2015/26501–1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) por


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Attribution-NonCommercial-NoDerivs 3.0 Brazil Exceto quando indicado o contrário, a licença deste item é descrito como Attribution-NonCommercial-NoDerivs 3.0 Brazil