The files provided here contain detailed analyzes of the association between hypoglycemic treatments and the risk of hospitalization for heart failure. The data used for such analyzes come from indexed publications and were retrieved from the following indexing bases: Medline (PubMed), ClinicalTrials.gov, Cochrane Central Register of Controlled Trials, Embase, European Union Clinical Trials Register, and World Health Organization (WHO ) International Clinical Trials Registry Platform electronic database entries until September 2020