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https://hdl.handle.net/20.500.12682/rdp/JQU2MR| DOI: | https://hdl.handle.net/20.500.12682/rdp/JQU2MR |
| Título: | Dataset on the role of spinal cord reactive oxygen species in sympathetic vasomotor activity in rats with experimental renovascular hypertension |
| Assunto: | Medicine, Health and Life Sciences |
| Descrição: | This dataset explores the role of spinal cord reactive oxygen species (ROS) in regulating sympathetic vasomotor activity in Goldblatt hypertensive rats (experimental renovascular hypertension). Hypertension was induced by clipping the renal artery, and six weeks later, a catheter was inserted into the subarachnoid space at the T10-11 vertebral level in urethane-anaesthetized rats. The effects of intrathecal Tempol injection on mean arterial pressure (MAP), heart rate (HR), renal sympathetic nerve activity (rSNA), and splanchnic sympathetic nerve activity (sSNA) were recorded over 60 minutes. Additionally, mRNA expression of oxidative balance enzymes was quantified in the spinal cord, and ROS levels were assessed using the DHE fluorescence method. |
| Autor(es): | Mano Tagliapietra da Silva, Fernanda |
| URI: | https://hdl.handle.net/20.500.12682/rdp/JQU2MR https://domusdados.unifesp.br/dataset.xhtml?amp;persistentId=hdl:20.500.12682/rdp/JQU2MR |
| Outros identificadores: | |
| Fomento: | FAPESP CAPES |
| Número do Projeto: | 2020/15318-0 88887.805849/2023-00 |
| Termo de uso: | |
| Data: | 21-Ago-2025 |
| Data de Disponibilização: | 12-Nov-2025 |
| Formato: | application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
| Tipo: | Dados experimentais Dados de fluorescência Dados de expressão gênica Dados funcionais Dados fisiológicos Dados estatísticos Dados comparativos Experimental data Fluorescence data Gene expression data Functional data Physiological data Statistical data Comparative data |
| Editora / Evento / Instituição: | Mano Tagliapietra da Silva, Fernanda |
| Idioma : | Portuguese |
| Aparece nas coleções: | Repositório de dados de pesquisa da UNIFESP |
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