Metabuscador de dados de pesquisa

DOI:	https://hdl.handle.net/11449/310297
Título:	Efeitos dos contaminantes ambientais terbacil e bromacil no metabolismo lipídico pró-esteatótico em cultura celular hepática e correlações com o metabolismo de uracila e a processos epigenéticos seguido de estudo translacional em Drosophila melanogaster Effects of terbacil and bromacil environmental contaminants on pro-steatotic lipid metabolism in liver cell culture and correlations with uracil metabolism and epigenetic processes followed by translational study in Drosophila melanogaster
Assunto:	Cultura de células;Drosophila melanogaster;Poluição;Análise translacional;Esteatose hepática
Descrição:	Resultados oriundos do desenvolvimento de projeto de pesquisa regular financiado pela FAPESP 2022/06302-8, realizado de 01/09/2022 a 28/02/2025. Para o desenvolvimento desse projeto, contamos com a participação de alunos de graduação e pós-graduação, que desenvolveram suas atividades com o modelo de cultura celular e com o modelo animal alternativo de drosophila melanogaster. Esses modelos foram submetidos a condições mimetizadoras de ambiente esteatótico e a diferentes concentrações de contaminantes ambientais (bromacil e terbacil), na sequência, células e animais foram coletados e utilizados em diferentes ensaios, cujos resultados são apresentados nos trabalhos finais dos alunos envolvidos, e também são depositados nesse repositório institucional - elementos do metabolismo (triglicerídeos, glicose, colesterol, NADH, NADPH), alterações e moléculas correlatos a processos oxidativos (ROS, potencial de membrana), análises de expressão de genes de elementos correlatos a várias vias metabólicas, e elementos correlatos aos mecanismos epigenéticos (metilação de DNA e RNA) e acetilação de histonas) . A metodologia detalhada utilizada se encontra em dissertação e trabalho de conclusão de cursos de graduação de alunos sob orientação da professora Karen CM Mores. Os resultados ainda não foram publicados em revistas especializadas, em sua maioria. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) FAPESP: 2022/06302-8
Autor(es):
URI:
Outros identificadores:	https://hdl.handle.net/11449/310297
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Número do Projeto:
Termo de uso:	info:eu-repo/semantics/restrictedAccess
Data:	9-Mai-2025 28-Fev-2025
Data de Disponibilização:
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Tipo:	info:eu-repo/semantics/dataset
Editora / Evento / Instituição:	Universidade Estadual Paulista (UNESP)
Idioma :	por
Aparece nas coleções:	Repositório Institucional UNESP

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