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https://repositorio.ufscar.br/handle/ufscar/15603| DOI: | https://doi.org/10.3389/fphys.2021.685274 |
| Título: | Proportional assist ventilation improves leg muscle reoxygenation after exercise in heart failure with reduced ejection fraction |
| Assunto: | Blood flow;Heart failure;Non-invasive ventilation;Hemodynamics;Exercise recovery |
| Descrição: | Background: Respiratory muscle unloading through proportional assist ventilation (PAV) may enhance leg oxygen delivery, thereby speeding off-exercise oxygen uptake (V.O2) kinetics in patients with heart failure with reduced left ventricular ejection fraction (HFrEF). Methods: Ten male patients (HFrEF = 26 ± 9%, age 50 ± 13 years, and body mass index 25 ± 3 kg m2) underwent two constant work rate tests at 80% peak of maximal cardiopulmonary exercise test to tolerance under PAV and sham ventilation. Post-exercise kinetics of V.O2, vastus lateralis deoxyhemoglobin ([deoxy-Hb + Mb]) by near-infrared spectroscopy, and cardiac output (QT) by impedance cardiography were assessed. Results: PAV prolonged exercise tolerance compared with sham (587 ± 390 s vs. 444 ± 296 s, respectively; p = 0.01). PAV significantly accelerated V.O2 recovery (τ = 56 ± 22 s vs. 77 ± 42 s; p < 0.05), being associated with a faster decline in Δ[deoxy-Hb + Mb] and QT compared with sham (τ = 31 ± 19 s vs. 42 ± 22 s and 39 ± 22 s vs. 78 ± 46 s, p < 0.05). Faster off-exercise decrease in QT with PAV was related to longer exercise duration (r = −0.76; p < 0.05). Conclusion: PAV accelerates the recovery of central hemodynamics and muscle oxygenation in HFrEF. These beneficial effects might prove useful to improve the tolerance to repeated exercise during cardiac rehabilitation. |
| Autor(es): | Silva, Audrey Borghi Goulart, Cássia da Luz Carrascosa, Cláudia R. Oliveira, Cristino Carneiro Berton, Danilo Cortozi Almeida, Dirceu Rodrigues de Nery, Luiz Eduardo Arena, Ross Neder, José Alberto |
| URI: | https://repositorio.ufscar.br/handle/ufscar/15603 |
| Outros identificadores: | https://doi.org/10.3389/fphys.2021.685274 |
| Fomento: | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) |
| Número do Projeto: | Processo nº 2015/26501–1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Processo nº 05/00722-0, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Processo nº 2018/03233-0, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Processo nº 443687/2018 - Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) |
| Termo de uso: | Attribution-NonCommercial-NoDerivs 3.0 Brazil |
| Data: | |
| Data de Disponibilização: | 15-Fev-2022 |
| Formato: | |
| Tipo: | Dataset |
| Editora / Evento / Instituição: | Universidade Federal de São Carlos |
| Idioma : | |
| Aparece nas coleções: | Repositório dados - UFSCar |
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