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DOI:	https://doi.org/10.1007/s10554-021-02402-0
Título:	Patterns of vascular response immediately after passive mobilization in patients with sepsis an observational transversal study
Assunto:	Endothelium;Exercise;Flow-mediated dilatation analysis;Inpatient
Descrição:	Sepsis is a serious organ dysfunction leading to endothelial damage in critical patients. Physiologically, there is an augment of vascular diameter in response to increased vascular blood flow and shear stress stimulus. However, the pattern of vascular response in face of passive mobilization (PM), an early mobilization physical strategy, has not yet been explored in patients with sepsis. To explore patterns of vascular response to PM and associations with clinical and cardiovascular profile in patients with sepsis. Cross-sectional, single-arm study. Thirty-two patients diagnosed with sepsis were enrolled. Vascular response was assessed by flow-mediated dilation (FMD) using brachial artery ultrasound, before and after PM. The PM (to assess the response pattern) and SR (shear rate) were also calculated. PM protocol consisted of knees, hips, wrists, elbows, shoulders, dorsiflexion/plantar flexion movements 3 × 10 repetitions each (15 min). Arterial stiffness was assessed by Sphygmocor®, by analyzing the morphology and pulse wave velocity. Cardiac autonomic modulation (CAM) was assessed by analyzing heart rate variability indexes (mean HR, RMSSD, LF, HF, ApEn, SampEn, DFA). Different vascular responses were observed after PM: (1) increased vascular diameter (responders) (n = 13, %FMD = 11.89 ± 5.64) and (2) reduced vascular diameter (non-responders) (n = 19, %FMD= -7.42 ± 6.44). Responders presented a higher non-linear DFA2 index (p = 0.02). There was a positive association between FMD and DFA (r = 0.529; p = 0.03); FMD and SampEn (r = 0.633; p < 0.01). A negative association was identified between FMD and LF (Hz) (r= -0.680; p < 0.01) and IL-6 (r= -0.469; p = 0.037) and SR and CRP (r= -0.427; p = 0.03).
Autor(es):	Kawakami, Débora Mayumi de Oliveira Bonjorno Junior, José Carlos Destro, Tamara Rodrigues da Silva Biazon, Thaís Marina Pires de Campos Garcia, Naiara Molina Bonjorno, Flávia Cristina Rossi Caruso Silva, Audrey Borghi Mendes, Renata Gonçalves
URI:	https://repositorio.ufscar.br/handle/ufscar/15583
Outros identificadores:	https://doi.org/10.1007/s10554-021-02402-0
Fomento:	Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do Projeto:	Processo nº 2015/26501–1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Código de Financiamento 001 - CAPES Processo nº 428073/2016-6 - Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Termo de uso:	Attribution-NonCommercial-NoDerivs 3.0 Brazil
Data:
Data de Disponibilização:	10-Fev-2022
Formato:
Tipo:	Dataset
Editora / Evento / Instituição:	Universidade Federal de São Carlos
Idioma :
Aparece nas coleções:	Repositório dados - UFSCar

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