Please use this identifier to cite or link to this item: https://repositorio.ufscar.br/handle/ufscar/15581
DOI: https://doi.org/10.1016/j.rmed.2021.106469
Title: Endothelial function provides early prognostic information in patients with COVID-19: a cohort study
Subject: COVID-19;Endothelium;Flow-mediated dilation (FMD);Hospitalization
Description: Background: The prothrombotic phenotype and diffuse intravascular coagulation observed in COVID-19 reflect endothelial dysfunction, which is linked to blood flow delivery deficiencies and cardiovascular risk. Assessments of detect vascular deficiencies among newly diagnosed and hospitalized patients due to COVID-19 have yet to be determined. Objective: To assess endothelial function characteristics in relation to length of hospitalization and mortality in patients diagnosed with COVID-19 and compare to patients without COVID-19. Methods: A prospective observational study involving 180 patients with confirmed COVID-19 (COVID-19 group) or suspected and ruled out COVID-19 (Non-COVID-19 group). Clinical evaluation and flow mediated vasodilation (FMD) were performed between the first 24-48 h of hospitalization. Patients were followed until death or discharge. Results: We evaluated 98 patients (COVID-19 group) and 82 (Non-COVID-19 group), COVID-19 group remained hospitalized longer and more deaths occurred compared to the Non-COVID-19 group (p = 0.01; and p < 0.01). Patients in COVID-19 group also had a significantly greater reduction in both FMDmm and FMD% (p < 0.01 in both). We found that absolute FMD≤0.26 mm and relative FMD≤3.43% were the ideal cutoff point to predict mortality and longer hospital stay. In Kaplan Meyer's analysis patients had a high probability of death within a period of up to 10 days of hospitalization. Conclusion: Patients hospitalized for COVID-19 present endothelial vascular dysfunction early, remained hospitalized longer and had a higher number of deaths, when compared with patients without COVID-19.
Authors: Oliveira, Murilo Rezende
Back, Guilherme Dionir
Goulart, Cássia da Luz
Domingos, Bianca Cristina
Arena, Ross
Silva, Audrey Borghi
URI: https://repositorio.ufscar.br/handle/ufscar/15581
Other Identifiers: https://doi.org/10.1016/j.rmed.2021.106469
Sponsorship: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Sponsor ID: Processo nº 2015/26501–1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Processo nº 2018/03233-0, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Código de Financiamento 001 - CAPES
Processo nº 141803/2019 -3 - Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Rights: Attribution-NonCommercial-NoDerivs 3.0 Brazil
Date:  
Available Data: 10-Feb-2022
Format:  
Type: Dataset
Publisher: Universidade Federal de São Carlos
Language :  
Appears in Collections:Repositório dados - UFSCar



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