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DOI:	https://doi.org/10.1016/j.rmed.2021.106511
Título:	Brain-heart autonomic axis across different clinical status and severity of chronic obstructive pulmonary disease
Assunto:	Acute exacerbation;Autonomic nervous system;Exercise;Heart rate variability;Respiratory disease
Descrição:	Purpose: Impairment of cardiac autonomic integrity is common in chronic obstructive pulmonary disease (COPD) patients. The influence of the interaction between clinical and severity status on brain-heart autonomic axis (BHAA) is not well known. We aimed to investigate the BHAA function across different clinical status and severity of COPD. Methods: Cross-sectional study involving 77 COPD patients allocated into four groups according to clinical status [acute exacerbation (GAE) or stable (GST)] and severity [less (-) or more (+)]: 1) GAE-, n = 13; 2) GAE+, n = 20; 3) GST-, n = 23; and 4) GST+, n = 21. Heart rate variability (HRV) at rest and heart rate recovery (HRR) after 6-min walk test were markers of BHAA. Mean R-R, STDRR, RMSSD, RRtri, HF, LF, SD1, SD2, ApEn and SampEn were the HRV indexes and, HRR was obtained as: HR at 1st min of recovery minus peak HR. Results: A main effect of clinical status (p < 0.001) was found to vagal modulation in GAE-vs. GST- (RMSSD: 25.0 ± 14.8 vs. 12.6 ± 5.5 ms; SD1: 18.0 ± 10.6 vs. 8.9 ± 3.9 ms) and to GAE + vs. GST+ (RMSSD: 26.4 ± 15.2 vs. 15.4 ± 6.3 ms; SD1: 18.3 ± 11.2 vs. 10.9 ± 4.5 ms). An effect of clinical status (p = 0.032) and severity (p = 0.030) were found to HF (vagal) in GAE + compared to GAE- and GST+ (264.7 ± 239.0 vs. 134.7 ± 169.7 and 135.8 ± 139.7 ms2). Lower HRR was found in GAE-compared to GST- (8.0 ± 2.4 vs. 19.6 ± 2.4 bpm), p = 0.002. Conclusion: In COPD patients, clinical status (AECOPD or stable) was more dominant than the severity on BHAA function. A more pronounced parasympathetic modulation was found in AECOPD patients with a lower HRR to exercise.
Autor(es):	Castello-Simões, Viviane Kabbach, Erika Zavaglia Schafauser, Nathany Souza Camargo, Patrícia Faria Simões, Rodrigo Polaquini Heubel, Alessandro Domingues Alqahtani, Jaber Saud Pereira, Mariana Brasil da Cunha Martino Sgarbosa, Nicole Marques Silva, Audrey Borghi Mendes, Renata Gonçalves
URI:	https://repositorio.ufscar.br/handle/ufscar/15572
Outros identificadores:	https://doi.org/10.1016/j.rmed.2021.106511
Fomento:	Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Número do Projeto:	Processo nº 2015/26501–1, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Código de Financiamento 001 - CAPES
Termo de uso:	Attribution-NonCommercial-NoDerivs 3.0 Brazil
Data:
Data de Disponibilização:	9-Fev-2022
Formato:
Tipo:	Dataset
Editora / Evento / Instituição:	Universidade Federal de São Carlos
Idioma :
Aparece nas coleções:	Repositório dados - UFSCar

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