Accelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen deposition

Araujo, Eliana Pereira de

Use este identificador para citar ou acessar este item: https://doi.org/10.25824/redu/IS3CZI

DOI:	https://doi.org/10.25824/redu/IS3CZI
Título:	Accelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen deposition
Assunto:	Medicine, Health and Life Sciences
Descrição:	Epidermal growth factor (EGF) promotes cell growth, proliferation and survival in diverses tissues. Piperonilic acid, a metabolite present in peppers (Piper nigrum L. and Piper longum L.), can bind to the epidermal growth factor receptor (EGFR) and cause an intracellular signaling cascade conducting to the transcription of genes responsible for for these actions, especially in keratinocytes. These cells are fundamental in maintaining skin homeostasis and are the first to be damaged in the event of a wound. Our hypothesis that piperonylic acid improves wound healing. Male C57BL6/J mice were subjected to dorsal skin wounds caused by a 6 mm punch and treated topically with piperonilic acid or vehicle. Wounds were evaluated macro and microscopically, and tissue samples were collected for immunofluorescence and real-time PCR analysis on days 6, 9, and 19 post-injury.
Autor(es):	Araujo, Eliana Pereira de
URI:	https://doi.org/10.25824/redu/IS3CZI https://redu.unicamp.br/dataset.xhtml?persistentId=doi:10.25824/redu/IS3CZI
Outros identificadores:
Fomento:	Fundação de Amparo à Pesquisa do Estado de São Paulo
Número do Projeto:	FAPESP: 2013/07607-8
Termo de uso:
Data:	14-Out-2021
Data de Disponibilização:	15-Out-2021
Formato:	text/tab-separated-values application/x-rar-compressed text/tab-separated-values text/tab-separated-values application/vnd.ms-excel application/vnd.ms-excel application/vnd.ms-excel application/vnd.ms-excel application/vnd.ms-excel application/vnd.ms-excel application/vnd.ms-excel application/vnd.ms-excel application/vnd.ms-excel
Tipo:
Editora / Evento / Instituição:	Pereira de Araujo, Eliana
Idioma :
Aparece nas coleções:	Repositório de Dados de Pesquisa da UNICAMP

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